Laboratory Diagnosis, Treatment and Prevention of Francisella tularensis


Francisella tularensis is a Gram-negative coccobacillus that causes tularemia, a zoonotic disease that can affect various organs and systems in humans and animals. The laboratory diagnosis of Francisella tularensis infection is challenging because of the low number of bacteria in clinical specimens, the fastidious growth requirements of the organism, and the high risk of infection for laboratory personnel. Therefore, a combination of methods is usually employed to confirm the diagnosis, including direct detection, culture and identification, antibody detection, and molecular methods.