Staphylococcus lugdunensis- An Overview


Staphylococcus lugdunensis is a type of coagulase-negative staphylococcus (CoNS) that is normally found on human skin but can cause various infections . It is a Gram-positive, spherical bacterium that grows in clusters and may have different colony colors and shapes . It was first described in 1988 and named after the city of Lyon, France, where it was isolated . It has a high pathogenic potential compared to other CoNS because of its virulence factors . It can cause skin and soft tissue infections, bone and joint infections, endocarditis, urinary tract infections, and peritonitis . It is usually susceptible to most antibiotics, but resistance to penicillin and methicillin may vary.

Some of the features that distinguish S. lugdunensis from other CoNS are:

  • It produces beta-hemolysis on blood agar .
  • It is positive for ornithine decarboxylase test .
  • It is negative for mannitol fermentation test .
  • It binds to von Willebrand factor and fibrinogen .
  • It forms proteinaceous biofilms .

S. lugdunensis is mainly associated with infections of the lower body regions, such as the perineal, inguinal, or pelvic areas . It can also colonize the nares and nasal cavity, but less frequently than other staphylococci . It is considered an opportunistic pathogen that can cause severe infections in immunocompromised individuals or those with foreign body implants . S. lugdunensis infections can mimic those caused by S. aureus, which is a more common and virulent staphylococcal species .

S. lugdunensis is an emerging pathogen that requires accurate identification and appropriate treatment. It can be easily overlooked or misidentified as a contaminant or a less virulent CoNS by routine laboratory methods . Therefore, it is important to use specific tests or molecular techniques to confirm its presence and susceptibility to antibiotics . S. lugdunensis infections can be prevented by maintaining good hygiene and sanitation, avoiding unnecessary use of medical devices, and seeking early diagnosis and treatment if symptoms occur.