Cell proliferation- Definition, assay, differentiation, diseases


  • Cell proliferation is the process by which a cell grows and divides to produce two daughter cells.
  • Cell proliferation leads to an exponential increase in cell number and is therefore a rapid mechanism of tissue growth.
  • Cell proliferation requires both cell growth and cell division to occur at the same time, such that the average size of cells remains constant in the population.
  • Cell proliferation is not synonymous with either cell growth or cell division, despite the fact that these terms are sometimes used interchangeably.
  • Cell proliferation is influenced by various factors, such as growth factors, enzymes, genes, hormones, nutrients, and signals from other cells .
  • Cell proliferation plays a vital role in normal development, tissue regeneration, wound healing, and immune response.
  • Cell proliferation also has implications for various diseases, such as cancer, fibrosis, arthritis, and neurodegeneration.
  • Cell proliferation can be measured by various methods that detect changes in cell number, DNA synthesis, metabolic activity, or specific antigens.