ORIGINAL ARTICLE: Brief Report: Long-Term Control of HIV by CCR5 Delta32/Delta32 Stem-Cell Transplantation (New England Journal of Medicine)
To infect cells, human immunodeficiency virus (HIV) binds the CD4 receptor and a chemokine coreceptor, CCR5 or CXCR4. In an HIV-infected patient with acute myelogenous leukemia, an allogeneic stem-cell transplantation was performed using a matched donor with a CCR5 variant that is resistant to HIV acquisition. Twenty months after successful transplantation, HIV remains undetectable in this …
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