Allogeneic Hematopoietic Stem-Cell Transplantation for Sickle Cell Disease
A modified conditioning protocol for allogeneic hematopoietic stem-cell transplantation that does not ablate the bone marrow was used to treat 10 adults who had severe sickle cell disease. The sickle cell phenotype was eliminated in 9 of the 10 recipients. No deaths, no major adverse events, and no graft-versus-host disease occurred among the recipients.
[Read the full article here]Related News:
Rituximab May Reduce Chronic GVDH After Stem Cell Transplantation
Preliminary study shows ‘mini’ stem cell transplantation may safely reverse severe sickle cell disease
“Mini” stem cell transplant may reverse severe sickle cell disease: study